The use of antidepressant drugs has become pervasive in modern American society. These drugs have been a salvation for many, leading users from profound depression to a productive life. Still, antidepressants are but one piece in the puzzle presented by anxiety and depression, and many patients find themselves in a seemingly endless revolving door of drug treatment and the psychiatry of the moment. These drugs are also part of a multibillion-dollar industry, and critics decry a system that has doctors promoting their use, in some cases likely because they’ve been offered lucrative speaking engagements and other incentives from pharmaceutical companies. And then there are allegations that antidepressants may have played a role in some recent mass shootings and other acts of violence. Are antidepressants a panacea, or are they a curse? Or, like so many modern issues, does the answer lie somewhere in between?